Creative Biostructure Provides Customized Membrane Protein Expression Services

Creative Biostructure uses both cell-based and cell-free systems to provide customized membrane protein expression services to customers in the pharmaceutical industry, as well as research institutions.

Shirley, United States - June 29, 2020 /MarketersMedia/ —

Creative Biostructure, a biotech company specialized in providing contract services to both academia and biotech industries in the field of structural biology, uses both cell-based and cell-free systems to provide customized membrane protein expression services to customers in the pharmaceutical industry, as well as research institutions.

Membrane proteins are involved in many cellular functions, including: signal transduction, cell adhesion, cell movement, transportation, and cell communication. Given its important role in cell function, membrane proteins are often considered to be perfect drug targets. In fact, about two-thirds of the approved drugs target membrane proteins, however, these account for only a small percentage of potential targets. Therefore, membrane proteins are still the main focus of new drug discovery.

Cell-based membrane protein expression
Both prokaryotic and eukaryotic protein expression systems are widely used. Bacterial systems have the advantage of high yield, which is necessary for X-ray crystallography or NMR experiments for structure determination. However, bacteria are not equipped with the complete equipment to complete the required post-translational modifications or correct folding, resulting in protein insolubility or loss of function. Therefore, a variety of eukaryotic cells, such as yeast, insect, plant and mammalian cells, have been developed to facilitate the expression of fully functional proteins.

Cell-free membrane protein expression
In vitro protein synthesis or cell-free protein synthesis (CFPS) is a method of producing proteins in the absence of viable cells but with cell extracts containing the necessary molecular mechanisms. The general cell extract used today is made from E. coli, wheat germ extract, rabbit reticulocyte lysate or insect cell lysate. Production of cell-free proteins can be achieved by adding templates encoding target proteins.

“We have also developed other systems including virus-like particles, liposome, nanodisc, animal-free and detergent-free systems to synthesize soluble and functional membrane proteins. Different systems has its own advantages. Our team will try to choose the most appropriate expression system to obtain high quality membrane proteins to fulfill your specific goals.” commented Joanna from the marketing department at Creative Biostructure.

If you feel interested and want to know more, you can visit https://www.creative-biostructure.com/protein-expression-service_57.htm.

Contact Info:
Name: Jerry Carter
Email: Send Email
Organization: Creative Biostructure
Address: 45-1 Ramsey Road, Shirley, New York 11967, USA
Website: https://www.creative-biostructure.com/

Source URL: https://marketersmedia.com/creative-biostructure-provides-customized-membrane-protein-expression-services/88966407

Source: MarketersMedia

Release ID: 88966407

Latest News

Putin engineers shakeup that could keep him in power longer

Jul 10, 2020

MOSCOW — President Vladimir Putin engineered a surprise shakeup of Russia's leadership Wednesday, proposing changes to the constitution that could keep him in power well past the end of his term in 2024. Prime Minister Dmitry Medvedev resigned his post after Putin announced the proposed constitutional amendments. Putin kept his longtime ally in the Kremlin's leadership structure, appointing him to the newly created post of deputy head of the presidential Security Council. The shakeup sent shock waves through Russia's political elites who were left pondering what Putin's intentions were and speculating about future Cabinet appointments. Putin’s proposed constitutional reforms, announced...

Sultan Qaboos bin Said, who modernized Oman, dies at 79

Jul 10, 2020

DUBAI, United Arab Emirates — Oman’s Sultan Qaboos bin Said, the Mideast's longest-ruling monarch who seized power in a 1970 palace coup and pulled his Arabian sultanate into modernity while carefully balancing diplomatic ties between adversaries Iran and the U.S., has died. He was 79. The British-educated, reclusive sultan reformed a nation that was home to only three schools and harsh laws banning electricity, radios, eyeglasses and even umbrellas when he took the throne. Under his reign, Oman became known as a welcoming tourist destination and a key Mideast interlocutor, helping the U.S. free captives in Iran and Yemen and...

On streets of Tehran, relief for now at no wider conflict

Jul 10, 2020

TEHRAN, Iran — Iranian newspapers proclaimed the country's attack on U.S. forces in Iraq to be "a dark night for Americans," and Washington's "first admission of failure in history." On the bustling streets of Tehran, however, there was relief Thursday that neither side appeared primed for war. “War is not something like the ‘Call of Duty’ game," said Dara Shojaei, a 23-year-old architecture student. “It's not a game you can play to win. There's no winner.” But with the relief came some mixed feelings about how far Iran should go to avenge the killing of Revolutionary Guard Gen. Qassem Soleiman,...

Stocks rise as China confirms trade deal signing next week

Jul 10, 2020

NEW YORK — U.S stocks climbed in morning trading on Thursday as investors cheered confirmation from China that its top trade official will head to Washington next week to sign a preliminary trade deal. The “Phase 1” accord is the opening step on a possible path toward a broader agreement between the nations. President Donald Trump has said he will travel to Beijing after the initial signing to start the second stage of talks. Every major index is on track for a record as Wall Street distances itself from a bout of anxiety over the last week because of tensions...

Soleimani, a general who became Iran icon by targeting US

Jul 10, 2020

TEHRAN, Iran — For Iranians whose icons since the Islamic Revolution have been stern-faced clergy, Maj. Gen. Qassem Soleimani widely represented a figure of national resilience in the face of four decades of U.S. pressure. For the U.S. and Israel, he was a shadowy figure in command of Iran's proxy forces, responsible for fighters in Syria backing President Bashar Assad and for the deaths of American troops in Iraq. Solemani survived the horror of Iran’s long war in the 1980s with Iraq to take control of the Revolutionary Guard’s elite Quds Force, responsible for the Islamic Republic’s foreign campaigns. Relatively...

Search

Deck Biz is an intelligent platform providing international and regional business news updates. You won’t get these insights elsewhere other than Deck Biz.

Contact us: sales@deckbiz.com